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0 · The TLR2 Binding Neisserial Porin PorB Enhances Antigen
1 · Structure and function of the PorB porin from disseminating
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6 · OpcA and PorB are novel bactericidal antigens of the 4CMenB
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8 · Gonococcal PorB: a multifaceted modulator of host immune
9 · Gonococcal OMV
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Pornhub is one of the most-visited websites in the world. Credit: Bob Al-Greene / Mashable. Before the emergence of "tube sites," websites where users upload often-pirated porn .porb Structure and function of the PorB porin from disseminatingThree of these proteins, OpcA, NspA, and PorB, triggered mouse antibodies that were bactericidal against several N. meningitidis strains.The most abundant gonococcal outer-membrane protein is PorB, an essential porin that facilitates ion exchange. Importantly, gonococcal PorB has several immunomodulatory .
PorB is capable of mounting an antigen specific T cell response by efficiently stimulating antigen cross-presentation in vivo and in vitro assessed by BMDC OT-I cocultivation .Neisseria gonorrhoeae secretes outer membrane vesicles (OMV) during colonization of epithelial cells. Here, the authors demonstrate that gonococcal OMVs induce epithelial .Structure and function of the PorB porin from disseminatingNeisseria gonorrhoeae PorBIA (PorB of serotype A) are associated with disseminating diseases and mediate a rapid bacterial invasion into host cells in a phosphate-sensitive .
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The mechanism by which PorB traffics form the bacterial outer membrane to host mitochondria remains unclear. Here, we utilized proteomics and super-resolution microscopy to show that N. . Gonococcal OMVs are able to deliver the outer membrane porin protein PorB to macrophage mitochondria to induce apoptosis 18, 19, while ectopic expression of PorB in epithelial cells induces a pre .
The structural model of PorB considered in the docking calculations was the X-ray structure of PorB solved by Kattner et al. (PDB entry 3VY8) 29 . Both zwitterionic and anionic forms of ampicillin . Neisseria gonorrhoeae is a human-specific pathogen responsible for the sexually transmitted infection, gonorrhoea. N. gonorrhoeae promotes its survival by manipulating both innate and adaptive immune responses. The most abundant gonococcal outer-membrane protein is PorB, an essential porin that facilitates ion exchange. . PorB has also been shown to increase total antigen-specific IgGs including IgG1, IgG2b, and IgG3 subtypes when used as an adjuvant. 23 These data suggest that PorB promotes both a Th1and Th2 antibody response, which is an ideal situation for producing a diverse array of protective antibodies. The identification of PorB as an additional bactericidal antigen in 4CMenB was less expected, although old studies performed on sera of patients convalescent from meningococcal disease showed .
The 25-34 age bracket accounts for over a quarter of the website's overall traffic. According to the insights page, this means that the average Pornhub visitor is now closer to 37 years old (which .porbOur results confirmed that loss of meningococcal PorB expression increases resistance to tetracycline ().Mutations in PorB also contribute to resistance to tetracycline in N. gonorrhoeae (9, 15).Recommended combination therapy for multiply resistant N. gonorrhoeae includes injectable ceftriaxone and oral doxycycline or azithromycin ().In .
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porb|Structure and function of the PorB porin from disseminating